AFE4500 Analog Front End (AFE) Texas Instruments AFE4500 Analog Front End (AFE) is a versatile signal acquisition system that supports three signal chains. An impedance measurement signal chain with integrated excitation and sense can be used for applications like Bio-impedance analysis (BIA), Electro-dermal analysis (EDA), and Impedance spectroscopy. An ECG receiver with a Right-leg drive (RLD) can enable the acquisition of a single-lead ECG from a pair of electrodes shared with the Bio-impedance measurement. A PPG signal chain comprises of a current driver for LEDs and a receiver that senses the signal from PDs. The outputs of the three signal chains in the Texas Instruments AFE4500 are digitized by a common ADC and stored in a FIFO, which can be read out using an SPI or I2C interface.